PARP1-IN-37
PARP1-IN-37 (Compound 8) is an orally active and selective poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor with an IC50 value of 24 nM for PARP1. PARP1-IN-37 inhibits PARP activity in cells with an EC50 value of 3.7 μM. PARP1-IN-37 is promising for research of BRCA-mutated tumors, such as breast and ovarian cancers.
For research use only. We do not sell to patients.
- CAS No.: 952474-39-4
- Formula: C14H11N3O
- Molecular Weight:237.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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PARP1 24 nM (IC50) |
PARP2 |
|
Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
3700 nM
Compound: 10
|
Inhibition of PARP in human HeLa cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay
Inhibition of PARP in human HeLa cells assessed as inhibition of hydrogen peroxide-induced PARylation by cell-based assay
|
[PMID: 25761096] |
| HeLa | EC50 |
3700 nM
Compound: 8
|
Inhibition of PARP in hydrogen peroxide-induced human HeLa cells assessed as inhibition DNA-damage-induced PARylation
Inhibition of PARP in hydrogen peroxide-induced human HeLa cells assessed as inhibition DNA-damage-induced PARylation
|
[PMID: 19873981] |
Chemical Information
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CAS No. 952474-39-4
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Molecular Weight 237.26
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Formula C14H11N3O
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SMILES
O=C(N)C1=CC=CC2=CN(N=C21)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)