1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. OUL35

OUL35 (Synonyms: NSC39047)

Cat. No.: HY-123512
Handling Instructions

OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM.

For research use only. We do not sell to patients.

OUL35 Chemical Structure

OUL35 Chemical Structure

CAS No. : 6336-34-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM[1].

IC50 & Target[1]

ARTD10/PARP10

329 nM (IC50)

In Vitro

OUL35 rescues HeLa cells from ARTD10-induced cell death and sensitizes cells to DNA damage. OUL35 (3 μM) binds to endogenous ARTD10 in U2OS cells[1].
OUL35 also inhibits ARTD8 (23.4 μM), ARTD4 (22.6 μM), and ARTD15 (4.17 μM) but with modest potency[1].
OUL35 makes hydrogen bonds to the amide and carbonyl of Gly888 and to the side-chain hydroxyl of Ser927. OUL35 stacks between Tyr919 and Tyr932, like 3AB in the crystal structure[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

256.26

Formula

C₁₄H₁₂N₂O₃

CAS No.
SMILES

O=C(C1=CC=C(C=C1)OC2=CC=C(C=C2)C(N)=O)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (325.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9023 mL 19.5114 mL 39.0229 mL
5 mM 0.7805 mL 3.9023 mL 7.8046 mL
10 mM 0.3902 mL 1.9511 mL 3.9023 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OUL35NSC39047OUL 35OUL-35NSC 39047NSC-39047PARPpoly ADP ribose polymeraseARTD10PARP10HeLaapoptosisDNAdamageInhibitorinhibitorinhibit

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OUL35
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