1. Anti-infection
    Cytoskeleton
    Cell Cycle/DNA Damage
    Autophagy
    Apoptosis
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Protein Tyrosine Kinase/RTK
  2. Parasite
    Microtubule/Tubulin
    Autophagy
    Apoptosis
    Reactive Oxygen Species
    VEGFR
    HIF/HIF Prolyl-Hydroxylase
    Antibiotic
    Bacterial
  3. Albendazole

Albendazole  (Synonyms: SKF-62979)

Cat. No.: HY-B0223 Purity: 99.00%
COA Handling Instructions

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells.

For research use only. We do not sell to patients.

Albendazole Chemical Structure

Albendazole Chemical Structure

CAS No. : 54965-21-8

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Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
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100 mg USD 66 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Albendazole:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

IC50 & Target

parasites, tubulin[1][2].
HIF-1α, VEGF[3].

In Vitro

Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner[1].
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle[1].
Albendazole (5 µM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner[2].
Albendazole (5 µM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells[2].
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKHEP-1 cells
Concentration: 100, 500, 1000 nM
Incubation Time: 1, 3, or 5 days
Result: Inhibited cell proliferation in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: SKHEP-1 HCC cells
Concentration: 100, 250, 500, 1000 nM
Incubation Time: 3 days
Result: Showed dose-dependent effect on the cell cycle kinetics.

Apoptosis Analysis[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 24, 36 h
Result: Promoted apoptosis in colon cancer cells.

Cell Autophagy Assay[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 24, 36 h
Result: Induced autophagy in colon cancer cells.

Western Blot Analysis[2]

Cell Line: HCT-15, HCT-1 16, HT29, SW480 cells
Concentration: 5 µM
Incubation Time: 12, 24, 36 h
Result: Induced apoptosis-related protein (PARP, caspase-3) and autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in a time-dependent manner.
Increased phosphorylation of different MAPKs (AMPK, ERK, JNK, p38) and ULK1 protein in a time dependent manner, and up-regulated the activation of different MAPKs.
Caused the activation of both MAPK and AMPK pathways.

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 500 nM
Incubation Time: 24 h
Result: Inhibited hypoxia-induced HIF-1α expression and VEGF expression in A549 cells.
In Vivo

Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice[4].
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (10-week-age; Echinococcus granulosus infection model)[4].
Dosage: 10 mg/kg
Administration: Oral gavage; once a day for 30 days.
Result: Reduced Echinococcus granulosus cyst weights.
Animal Model: Male BALB/c Nu/Nu mice (6 to 10-week-old; inoculated subcutaneously with SKHEP-1)[1].
Dosage: 50, 150, 300 mg/kg
Administration: Oral administration; per day in two divided dose for 20 days.
Result: Profoundly suppressed tumor growth in vivo.
Clinical Trial
Molecular Weight

265.33

Formula

C12H15N3O2S

CAS No.
SMILES

O=C(OC)NC1=NC2=CC=C(SCCC)C=C2N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (75.38 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7689 mL 18.8445 mL 37.6889 mL
5 mM 0.7538 mL 3.7689 mL 7.5378 mL
10 mM 0.3769 mL 1.8844 mL 3.7689 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2 mg/mL (7.54 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (7.54 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.00%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Albendazole
Cat. No.:
HY-B0223
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