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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Clusterin alpha Chain Antibody (YA2525)

Clusterin alpha Chain Antibody (YA2525)

Cat. No.: HY-P82780
COA
SDS
User Guide for Antibodies Technical Support

Clusterin alpha Chain Antibody (YA2525) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Clusterin alpha Chain.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

Descripciòn

Clusterin alpha Chain Antibody (YA2525) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Clusterin alpha Chain.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Peso molecular
Predicted band size: 52 kDa;
Observed band size: 52 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein of mouse Clusterin alpha chain
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
IHC
 
1:50-1:100
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Solution
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed:14741101). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (PubMed:12551933). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. Following ER stress, suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. When secreted, does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). When secreted, acts as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (PubMed:11865066)
Subcellular Localization：Secreted; Nucleus; Cytoplasm; Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytosol; Microsome; Endoplasmic reticulum; Mitochondrion; Mitochondrion membrane; Cytoplasm, perinuclear region; Cytoplasmic vesicle, secretory vesicle, chromaffin granule
Expression：
Tissue_specificity:Most abundant in stomach, liver, brain, and testis, with intermediate levels in heart, ovary and kidney
Subunit：Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers. Interacts with a broad range of misfolded proteins, including APP, APOC2 and LYZ.
Database

Entrez Gene: 24854 Rat

SwissProt: P05371 

Research Field

Immunology
Synonyms
Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; AI893575; D14Ucla3
Documentación
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Clusterin alpha Chain Antibody (YA2525) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
Clusterin alpha Chain Antibody (YA2525)
Cat. No.:
HY-P82780
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