Clu - clusterin Gene

Also Known as Cli; ApoJ; Sgp2; SP-40; Sgp-2; Sugp-2; D14Ucla3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12759

Summary

The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. [provided by RefSeq, Nov 2015]

Clu Products (1)

mRNA Protein Name
NM_013492.3 NP_038520.2 clusterin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12551933 MGI
Biological Process GO Annotation Evidence References Source
involved in immune complex clearance IMP
IMP: Inferred from mutant phenotype
11865066 MGI
involved in negative regulation of amyloid fibril formation IMP
IMP: Inferred from mutant phenotype
14741101 MGI
involved in positive regulation of amyloid-beta formation IMP
IMP: Inferred from mutant phenotype
12145324 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
12551933 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12551933 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22197644 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
22197644 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12551933 MGI
is active in synapse EXP
EXP: Inferred from Experiment
16452087 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16452087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

clusterin

  • Apolipoprotein J

  • clustrin

  • complement lysis inhibitor

  • sulfated glycoprotein 2

  • testosterone repressed prostate message

  • testosterone repressed prostate message-2

Recombinant Clu Proteins

Cat. No. Product Name Accession Purity
HY-P70058 Clusterin/APOJ Protein, Mouse (HEK293, His) Q06890 (E22-E448) ≥ 95%, as determined by reducing SDS-PAGE.

Clu Antibodies

Cat. No. Product Name Application Reactivity
HY-P82780 Clusterin alpha Chain Antibody (YA2525) WB, ICC/IF, IP Mouse, Rat
HY-P82780A Clusterin alpha Chain Antibody (YA2525)(PBS only) WB, ICC/IF, IP Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02848 CLU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17319 Clu Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23774 Clu Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clu NCBI NCBI:1191