1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. Venadaparib

Venadaparib (Synonyms: IDX-1197)

Cat. No.: HY-137457
Handling Instructions

Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib does not sensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSB) and can be used for solid tumors research.

For research use only. We do not sell to patients.

Venadaparib Chemical Structure

Venadaparib Chemical Structure

CAS No. : 1681017-83-3

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Description

Venadaparib (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib does not sensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSB) and can be used for solid tumors research[1][2].

IC50 & Target[1]

PARP1

1.4 nM (IC50)

PARP2

1 nM (IC50)

In Vitro

In DNA damage-induced Hela cells, Venadaparib (IDX-1197) significantly inhibits PARP1-mediated PAR expression (EC50 of 0.5 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.45

Formula

C₂₃H₂₃FN₄O₂

CAS No.
SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CC(CNC4CC4)C3)=O)=C2)C5=C1C=CC=C5

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VenadaparibIDX-1197IDX1197IDX 1197PARPpoly ADP ribose polymeraseanticancersolidtumorsInhibitorinhibitorinhibit

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