1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. Venadaparib hydrochloride

Venadaparib hydrochloride (Synonyms: IDX-1197 hydrochloride)

Cat. No.: HY-137457A
Handling Instructions

Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research.

For research use only. We do not sell to patients.

Venadaparib hydrochloride Chemical Structure

Venadaparib hydrochloride Chemical Structure

CAS No. : 1681020-60-9

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Description

Venadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research[1][2].

IC50 & Target[1]

PARP1

1.4 nM (IC50)

PARP2

1 nM (IC50)

In Vitro

Venadaparib (example 143; 6-10 days) shows potent growth inhibition of MDA-MB-436 cells and Capan-1 pancreatic cancer cells with IC50 values of ≤5nM and 50nM [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the germline BRCA1-mutated ovarian cancer PDX model, oral administration of Venadaparib (IDX-1197) exhibits significant PAR inhibition (>90%) in tumor tissues until 24 hr post dose. Venadaparib also dose-dependently led to potent tumor growth inhibition compared to Olaparib treatment group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

442.91

Formula

C₂₃H₂₄ClFN₄O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Venadaparib hydrochloride
Cat. No.:
HY-137457A
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