Satratoxin G 

Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase ^[1][2].

Satratoxin G (40 nM, 6 h) induces the cleavage of caspase-3 and ADP-ribose polymerase (PARP) in HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Satratoxin G (500 μg/kg, intranasal instillation) can induce the apoptosis of olfactory sensory neurons in mouse olfactory epithelium, and express IL-1α, IL-1β, IL-6, TNF-α and MIP-2 genes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

544.59

C₂₉H₃₆O₁₀

53126-63-9

CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@](C[C@H]3OC(/C=C\C=C\[C@@]5(C(O)C)[C@H](O)[C@@]6(C7O6)CCO5)=O)([H])O2)(COC7=O)CC1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nagase M, et al. Molecular mechanism of satratoxin-induced apoptosis in HL-60 cells: activation of caspase-8 and caspase-9 is involved in activation of caspase-3. Immunol Lett. 2002 Oct 21;84(1):23-7.  [Content Brief]

  [2]. Islam Z, et al. Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ Health Perspect. 2006 Jul;114(7):1099-107.  [Content Brief]