1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
    Apoptosis
  2. Microtubule/Tubulin
    ADC Cytotoxin
    Apoptosis
  3. Tubulysin A

Tubulysin A (Synonyms: TubA)

Cat. No.: HY-15995
Handling Instructions

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

For research use only. We do not sell to patients.

Tubulysin A Chemical Structure

Tubulysin A Chemical Structure

CAS No. : 205304-86-5

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Description

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

IC50 & Target

Traditional Cytotoxic Agents

 

Molecular Weight

844.07

Formula

C₄₃H₆₅N₅O₁₀S

CAS No.

205304-86-5

SMILES

O=C([[email protected]@]([[email protected]@H](C)CC)([H])NC([[email protected]@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[[email protected]@H](C(C)C)C[[email protected]](C2=NC(C(N[[email protected]](C[[email protected]](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Tubulysin ATubAMicrotubule/TubulinADC CytotoxinApoptosisInhibitorinhibitorinhibit

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Tubulysin A
Cat. No.:
HY-15995
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