1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. ADC Cytotoxin
    Microtubule/Tubulin

Tubulysin A (Synonyms: TubA)

Cat. No.: HY-15995
Handling Instructions

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.

For research use only. We do not sell to patients.
Tubulysin A Chemical Structure

Tubulysin A Chemical Structure

CAS No. : 205304-86-5

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1 mg $1720 Backordered
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Description

Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. IC50 value: Target: microtubule Tubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range.

Clinical Trial
Sponsor Condition Start Date Phase
Endocyte Solid Tumors; Triple-Negative Breast Cancer (TNBC); Advanced Non-Small Cell Lung Cancer (NSCLC); Ovarian Cancer; Hepatocellular Carcinoma (HCC) Phase 1
References
M.Wt

844.07

Formula

C₄₃H₆₅N₅O₁₀S

CAS No.

205304-86-5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Tubulysin A
Cat. No.:
HY-15995
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