1. Cell Cycle/DNA Damage
    Epigenetics
    Autophagy
  2. PARP
    Autophagy
    Mitophagy
  3. Olaparib D8

Olaparib D8 (Synonyms: AZD2281 D8; KU0059436 D8)

Cat. No.: HY-10162S1
Handling Instructions

Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.

For research use only. We do not sell to patients.

Olaparib D8 Chemical Structure

Olaparib D8 Chemical Structure

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Description

Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4].

Molecular Weight

442.51

Formula

C₂₄H₁₅D₈FN₄O₃

SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3C([2H])([2H])C([2H])([2H])N(C(C4CC4)=O)C([2H])([2H])C3([2H])[2H])=O)=C2)C5=C1C=CC=C5

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Olaparib D8AZD2281 D8 KU0059436 D8Olaparib D 8Olaparib D-8PARPAutophagyMitophagypoly ADP ribose polymerase Mitochondrial AutophagyInhibitorinhibitorinhibit

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Olaparib D8
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