PARP1-IN-5
Based on 1 publication(s) in Google Scholar
PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2735645-53-9
- Formula: C25H24N2O5S
- Molecular Weight:464.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) PARP1-IN-5
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Biological Activity
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PARP-1 14.7 nM (IC50) |
PARP-2 0.9 μM (IC50) |
PARP1-IN-5 (0.1~10 μM; A549 cells) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 (0.1~10 μM; SK-OV-3 cells) decreases the expressions of MCM2-7. PARP1-IN-5 (0.1~320 μM; A549 cells) has little cytotoxic effects on A549 cells. PARP1-IN-5 (SK-OV-3 cells) can significantly decrease the PAR level[1].
PARP1-IN-5 exerts antitumor effects through PARP-1. PARP1-IN-5 could increase the γ-H2AX expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
PARP1-IN-5 (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg[1].
PARP1-IN-5 (50 mg/kg; p.o.) positively correlates with the expression of PARP-1[1].
PARP1-IN-5 can upregulate the expression of γ-H2AX and decrease the expression of PAR[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:1000 mg/kg
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Administration:P.o.
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Result:There was no significant difference in the body weight and blood routine.
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Animal Model:Mice[1]
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Dosage:25 and 50 mg/kg
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Administration:P.o.; 12 days
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Result:Significantly enhanced the inhibitory effect of CBP on A549 cells at 50 mg/kg.
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Animal Model:Male Sprague−Dawley (SD) rats[1]
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Dosage:50 mg/kg (Pharmacokinetic Analysis)
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Administration:P.o.; 12 days
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Result:Positively correlated with the expression of PARP-1.
Chemical Information
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CAS No. 2735645-53-9
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Molecular Weight 464.53
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Formula C25H24N2O5S
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SMILES
O=C1C=C(OC2=C1C(O)=CC(O)=C2CN3CCN(CC3)CC4=CC=CS4)C5=CC=C(C=C5)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Apoptosis
Excessive hydrogen sulfide causes lung and brain tissue damage by promoting PARP1/Bax and C9 and inhibiting LAMB1. [Abstract]2022 Feb;27(1-2):149-160. PMID: 35119561
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1-IN-5 Related Classifications
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