2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. PARP Apoptosis
  4. PARP-2-IN-2

PARP-2-IN-2 (compound 27) is a PARP‑2 inhibitor with an IC50 value of 0.057 µM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer.

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PARP-2-IN-2 Chemical Structure

PARP-2-IN-2 Chemical Structure

CAS No. : 2915651-00-0

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PARP-2-IN-2 Related Antibodies

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Description

PARP-2-IN-2 (compound 27) is a PARP‑2 inhibitor with an IC50 value of 0.057 µM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer[1].
IC50 & Target

IC50: 0.057 µM (PARP‑2), 11.32 µM (MDA-MB-231 cells), 16.70 µM (MCF-7 cells)[1]
In Vitro

PARP-2-IN-2 (0-1 μM; 1 h) inhibits PARP‑2 with an IC50 value of 0.057 µM[1].
PARP-2-IN-2 (0-100 μM; 24 h) shows cytotoxicity to MDA-MB-231 and MCF-7 cancer cells[1].
PARP-2-IN-2 (16.7 μM; 24 h) induces cell cycle arrest and apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PARP-2-IN-2 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231 and MCF-7 cell lines
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed in vitro cytotoxicity to MDA-MB-231 and MCF-7 cells with IC50 values of 11.32 and 16.70 µM, respectively.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 16.70 µM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G1/S phase with cells in pre-G1 phase increased from 1.85 to 25.91%.

Apoptosis Analysis[1]

Cell Line: MCF-7 cell line
Concentration: 16.70 µM
Incubation Time: 24 h
Result: Induced potent apoptotic and weak necrotic effect in MCF-7 breast cancer cell line.
Molecular Weight

371.86

Formula

C20H22ClN3O2
CAS No.
SMILES

O=C(NC1=CC=C(C2=NC3=CC(Cl)=CC=C3O2)C=C1)CCN(CC)CC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PARP-2-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP-2-IN-22915651-00-0PARPApoptosispoly ADP ribose polymerase benzoxazole derivativebreast cancersorafenibolaparibcell cycle arrestapoptosisnecroticInhibitorinhibitorinhibit

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