PARP-2-IN-2
PARP-2-IN-2 (compound 27) is a PARP 2 inhibitor with an IC50 value of 0.057 μM. PARP-2-IN-2 induces cell cycle arrest and apoptosis of MCF-7 breast cancer cells. PARP-2-IN-2 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2915651-00-0
- Formula: C20H22ClN3O2
- Molecular Weight:371.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.057 μM (PARP 2), 11.32 μM (MDA-MB-231 cells), 16.70 μM (MCF-7 cells)[1]
PARP-2-IN-2 (0-1 μM; 1 h) inhibits PARP 2 with an IC50 value of 0.057 μM[1]. PARP-2-IN-2 (0-100 μM; 24 h) shows cytotoxicity to MDA-MB-231 and MCF-7 cancer cells[1]. PARP-2-IN-2 (16.7 μM; 24 h) induces cell cycle arrest and apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 and MCF-7 cell lines
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Concentration:0-100 μM
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Incubation Time:24 h
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Result:Showed in vitro cytotoxicity to MDA-MB-231 and MCF-7 cells with IC50 values of 11.32 and 16.70 µM, respectively.
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Cell Line:MCF-7 cell line
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Concentration:16.70 µM
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Incubation Time:24 h
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Result:Induced cell cycle arrest at G1/S phase with cells in pre-G1 phase increased from 1.85 to 25.91%.
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Cell Line:MCF-7 cell line
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Concentration:16.70 µM
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Incubation Time:24 h
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Result:Induced potent apoptotic and weak necrotic effect in MCF-7 breast cancer cell line.
Chemical Information
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CAS No. 2915651-00-0
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Molecular Weight 371.86
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Formula C20H22ClN3O2
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SMILES
O=C(NC1=CC=C(C2=NC3=CC(Cl)=CC=C3O2)C=C1)CCN(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP-2-IN-2 Related Classifications
HY-151624 Related Classifications
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