Phospholipase C beta 1 Antibody (YA1626)
(Synonyms: Plcb; AI132408; mKIAA0581; 3110043I21Rik)Phospholipase C beta 1 Antibody (YA1626) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospholipase C beta 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
Phospholipase C beta 1 Antibody (YA1626) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospholipase C beta 1.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityRat
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Observed Molecular WeightObserved band size: 138 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 138 kDa
Entrez Gene: 24654 Rat
SwissProt: P10687 Rat
Recombinant protein of mouse Phospholipase C beta 1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Phospholipase C beta 1 catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier[1].
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Subcellular Localization
Nucleus membrane; Cytoplasm
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Isoforms & Post-Translational Modification
Q9Z1B3 has 3 isomers: Q9Z1B3-1: 138396 Da (predicted); Q9Z1B3-2: 133327 Da (predicted); Q9Z1B3-3: 136309 Da (predicted).
Palmitoylated (PubMed:27653213). Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier (Probable). Palmitoylation by ZDHHC21 is stimulated by inflammation (PubMed:27653213) -
Subunit
Interacts with DGKQ
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SwissProt ID
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Synonyms
Plcb; AI132408; mKIAA0581; 3110043I21Rik
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Research Field
Signal Transduction
Documentation
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