Plcb1 - phospholipase C, beta 1 Gene

Also Known as Plcb; mKIAA0581; 3110043I21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18795

Summary

Enables lamin binding activity and phosphatidylinositol Phospholipase C activity. Involved in several processes, including positive regulation of cell cycle process; regulation of cellular macromolecule biosynthetic process; and regulation of trans-synaptic signaling. Located in several cellular components, including chromatin; glutamatergic synapse; and nuclear speck. Part of protein-containing complex. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study Alzheimer's disease and schizophrenia. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 12 and myelodysplastic syndrome. Orthologous to human PLCB1 (Phospholipase C beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Plcb1 Products (2)

mRNA Protein Name
NM_001145830.1 NP_001139302.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
NM_019677.2 NP_062651.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lamin binding IPI
IPI: Inferred from physical interaction
19028838 MGI
enables phosphatidylinositol phospholipase C activity IDA
IDA: Inferred from direct assay
9762362 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17022104 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9305844 MGI
involved in G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
19028838 MGI
involved in activation of meiosis involved in egg activation IDA
IDA: Inferred from direct assay
14499343 MGI
involved in cerebral cortex development IMP
IMP: Inferred from mutant phenotype
11224545 MGI
involved in fat cell differentiation IDA
IDA: Inferred from direct assay
19385066 MGI
involved in glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11224545 MGI
involved in insulin-like growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9187110 MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31268747 MGI
involved in ligand-gated ion channel signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
18493969 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12031797 MGI
involved in negative regulation of monocyte extravasation IDA
IDA: Inferred from direct assay
19687358 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31268747 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26075576 MGI
involved in positive regulation of CD24 production IDA
IDA: Inferred from direct assay
15849202 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15849202 MGI
involved in positive regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
10913438 MGI
involved in positive regulation of acrosome reaction IMP
IMP: Inferred from mutant phenotype
11464583 MGI
involved in positive regulation of developmental growth IMP
IMP: Inferred from mutant phenotype
15474310 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
11464583 MGI
involved in positive regulation of insulin secretion IGI
IGI: Inferred from genetic interaction
10570150 MGI
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
26075576 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
9444325 MGI
involved in positive regulation of myoblast differentiation IDA
IDA: Inferred from direct assay
15174099 MGI
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
16339037 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
16339037 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16339037 MGI
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18493969 MGI
involved in regulation of establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
27653213 MGI
involved in regulation of fertilization IMP
IMP: Inferred from mutant phenotype
11464583 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid IDA
IDA: Inferred from direct assay
15664177 MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid IMP
IMP: Inferred from mutant phenotype
15664177 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
15664177 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
15664177 MGI
located in chromatin IDA
IDA: Inferred from direct assay
19028838 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15849202 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16339037 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16339037 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16339037 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
17022104 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10913438 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
18973591 MGI
is active in postsynaptic cytosol IEP
IEP: Inferred from expression pattern
18973591 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
27353086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

  • PLC-154

  • PLC-beta-1

  • phosphoinositide phospholipase C

  • phosphoinositide phospholipase C-beta-1

  • phospholipase C-beta-1a

Plcb1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81881 Phospholipase C beta 1 Antibody (YA1626) WB Rat
HY-P81881A Phospholipase C beta 1 Antibody (YA1626)(PBS only) WB Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10652 PLCB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21691 Plcb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28209 Plcb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plcb1 NCBI NCBI:23236