PARP11 inhibitor ITK7  (Synonyms: ITK7)

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC₅₀ value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization^[1]. PARP11 inhibitor ITK7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50: 14 nM (PARP11); 13 nM (PARP11-dependent auto-MARylation)^[1]

PARP11 inhibitor ITK7 (ITK7) can potently inhibit PARP11 with an IC₅₀ value of 14 nM^[1].
ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation with an EC₅₀ value of 13 nM^[1].
ITK7 (0, 0.03, 0.1, 0.3, 1, 3 μM; 3 h) inhibits PARP11 auto-MARylation activity in cells and causes PARP11 to dissociate from the nuclear envelope^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

322.38

C₁₇H₁₄N₄OS

2411890-36-1

Solid

White to off-white

O=C1NC(CSC2=NC=CC=N2)=NC3=C1C=CC(C#CC)=C3C

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Kirby, Ilsa T et al. A Potent and Selective PARP11 Inhibitor Suggests Coupling between Cellular Localization and Catalytic Activity. Cell chemical biology vol. 25,12 (2018): 1547-1553.e12.  [Content Brief]