PARP7-IN-17
Based on 1 Customer Validation
PARP7-IN-17 is a potent inhibitor of PARP7 with IC50 of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 3024030-10-9
- Formula: C20H20F3N7O2
- Molecular Weight:447.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP7 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| AML12 | IC50 |
>50 μM
Compound: (S)-XY-05
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Antiproliferative activity against mouse AML12 cells measured after 6 days incubation by MTT assay
Antiproliferative activity against mouse AML12 cells measured after 6 days incubation by MTT assay
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[PMID: 38059836] |
| CT26 | IC50 |
16.17 μM
Compound: (S)-XY-05
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Antiproliferative activity against mouse CT26 cells measured after 6 days incubation by MTT assay
Antiproliferative activity against mouse CT26 cells measured after 6 days incubation by MTT assay
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[PMID: 38059836] |
| CT26 | IC50 |
36.07 μM
Compound: (S)-XY-05
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Antiproliferative activity against mouse CT26 cells measured after 6 days incubation by CTG assay
Antiproliferative activity against mouse CT26 cells measured after 6 days incubation by CTG assay
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[PMID: 38059836] |
Chemical Information
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CAS No. 3024030-10-9
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Appearance Solid
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Molecular Weight 447.41
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Formula C20H20F3N7O2
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Color White to off-white
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SMILES
O=C(C1=CC=CC2=CN(N=C21)[C@@H](C)C(N3CCN(CC3)C4=NC=C(C=N4)C(F)(F)F)=O)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (111.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2351 mL | 11.1754 mL | 22.3509 mL | 55.8772 mL |
| 5 mM | 0.4470 mL | 2.2351 mL | 4.4702 mL | 11.1754 mL | |
| 10 mM | 0.2235 mL | 1.1175 mL | 2.2351 mL | 5.5877 mL | |
| 15 mM | 0.1490 mL | 0.7450 mL | 1.4901 mL | 3.7251 mL | |
| 20 mM | 0.1118 mL | 0.5588 mL | 1.1175 mL | 2.7939 mL | |
| 25 mM | 0.0894 mL | 0.4470 mL | 0.8940 mL | 2.2351 mL | |
| 30 mM | 0.0745 mL | 0.3725 mL | 0.7450 mL | 1.8626 mL | |
| 40 mM | 0.0559 mL | 0.2794 mL | 0.5588 mL | 1.3969 mL | |
| 50 mM | 0.0447 mL | 0.2235 mL | 0.4470 mL | 1.1175 mL | |
| 60 mM | 0.0373 mL | 0.1863 mL | 0.3725 mL | 0.9313 mL | |
| 80 mM | 0.0279 mL | 0.1397 mL | 0.2794 mL | 0.6985 mL | |
| 100 mM | 0.0224 mL | 0.1118 mL | 0.2235 mL | 0.5588 mL |
PARP7-IN-17 Related Classifications
HY-163081 Related Classifications
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