AMXI-5001 hydrochloride
Based on 1 Customer Validation
AMXI-5001 hydrochloride is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 hydrochloride exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride induces complete regression of established tumors, including exceedingly large tumors.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 2923879-23-4
- Formula: C25H21ClFN5O3
- Molecular Weight:493.92
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2923879-23-4
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Appearance Solid
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Molecular Weight 493.92
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Formula C25H21ClFN5O3
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Color White to off-white
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SMILES
[H]Cl.O=C(NC1=NC2=C(N1)C=C(C3=C(F)C=CC(CC4=NNC(C5=C4C=CC=C5)=O)=C3)C=C2)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (202.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0246 mL | 10.1231 mL | 20.2462 mL | 50.6155 mL |
| 5 mM | 0.4049 mL | 2.0246 mL | 4.0492 mL | 10.1231 mL | |
| 10 mM | 0.2025 mL | 1.0123 mL | 2.0246 mL | 5.0615 mL | |
| 15 mM | 0.1350 mL | 0.6749 mL | 1.3497 mL | 3.3744 mL | |
| 20 mM | 0.1012 mL | 0.5062 mL | 1.0123 mL | 2.5308 mL | |
| 25 mM | 0.0810 mL | 0.4049 mL | 0.8098 mL | 2.0246 mL | |
| 30 mM | 0.0675 mL | 0.3374 mL | 0.6749 mL | 1.6872 mL | |
| 40 mM | 0.0506 mL | 0.2531 mL | 0.5062 mL | 1.2654 mL | |
| 50 mM | 0.0405 mL | 0.2025 mL | 0.4049 mL | 1.0123 mL | |
| 60 mM | 0.0337 mL | 0.1687 mL | 0.3374 mL | 0.8436 mL | |
| 80 mM | 0.0253 mL | 0.1265 mL | 0.2531 mL | 0.6327 mL | |
| 100 mM | 0.0202 mL | 0.1012 mL | 0.2025 mL | 0.5062 mL |
AMXI-5001 hydrochloride Related Classifications
HY-145734A Related Classifications
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