2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. AMXI-5001 hydrochloride

AMXI-5001 hydrochloride is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 hydrochloride exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride induces complete regression of established tumors, including exceedingly large tumors.

For research use only. We do not sell to patients.

AMXI-5001 hydrochloride Chemical Structure

AMXI-5001 hydrochloride Chemical Structure

Size Price Stock Quantity
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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AMXI-5001 hydrochloride Related Antibodies

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Description

AMXI-5001 hydrochloride is a potent, orally active, and dual parp1/2 and microtubule polymerization inhibitor. MXI-5001 hydrochloride exhibits selective antitumor cytotoxicity across a wide variety of human cancer cells with much lower IC50s than existing clinical PARP1/2 inhibitors. AMXI-5001 hydrochloride induces complete regression of established tumors, including exceedingly large tumors[1].

Clinical Trial
Molecular Weight

493.92

Formula

C25H21ClFN5O3
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C(NC1=NC2=C(N1)C=C(C3=C(F)C=CC(CC4=NNC(C5=C4C=CC=C5)=O)=C3)C=C2)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0246 mL 10.1231 mL 20.2462 mL
5 mM 0.4049 mL 2.0246 mL 4.0492 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0246 mL 10.1231 mL 20.2462 mL 50.6155 mL
5 mM 0.4049 mL 2.0246 mL 4.0492 mL 10.1231 mL
10 mM 0.2025 mL 1.0123 mL 2.0246 mL 5.0615 mL
15 mM 0.1350 mL 0.6749 mL 1.3497 mL 3.3744 mL
20 mM 0.1012 mL 0.5062 mL 1.0123 mL 2.5308 mL
25 mM 0.0810 mL 0.4049 mL 0.8098 mL 2.0246 mL
30 mM 0.0675 mL 0.3374 mL 0.6749 mL 1.6872 mL
40 mM 0.0506 mL 0.2531 mL 0.5062 mL 1.2654 mL
50 mM 0.0405 mL 0.2025 mL 0.4049 mL 1.0123 mL
60 mM 0.0337 mL 0.1687 mL 0.3374 mL 0.8436 mL
80 mM 0.0253 mL 0.1265 mL 0.2531 mL 0.6327 mL
100 mM 0.0202 mL 0.1012 mL 0.2025 mL 0.5062 mL
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AMXI-5001 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMXI-5001AMXI5001AMXI 5001Microtubule/Tubulinoralparp1/2microtubule polymerizationantitumor cytotoxicitycomplete regressionlarge tumorInhibitorinhibitorinhibit

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