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Referencia número: HY-141486A

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PROTAC PARP/EGFR ligand 1

PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology.

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No. CAS: 2661609-57-8
Fòrmula: C₅₃H₅₆ClF₂N₉O₈
Peso molecular:1020.52

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PROTAC PARP/EGFR ligand 1 Chemical Structure

No. CAS: 2661609-57-8

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Actividad biológica

Descripciòn

PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology^[1].

Ver todos los productos específicos de isoformas PARP :

Ver todos los productos específicos de isoformas EGFR :

Chemical Information

No. CAS 2661609-57-8
Peso molecular 1020.52
Fòrmula C₅₃H₅₆ClF₂N₉O₈
SMILES

COC(C(OCCCCCC(N[C@@H](COCC#C)C(NCCCCCC(N1CCN(CC1)C(C2=CC(CC(C3=CC=CC=C34)=NNC4=O)=CC=C2F)=O)=O)=O)=O)=C5)=CC6=C5C(NC7=CC(Cl)=C(C=C7)F)=NC=N6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Mengzhu Zheng, et al. Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP. J Med Chem. 2021 Jun 10;64(11):7839-7852. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PROTAC PARP/EGFR ligand 1

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Chemical Information
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PROTAC PARP/EGFR ligand 1

Ver todos los productos específicos de isoformas PARP

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PROTAC PARP/EGFR ligand 1 Related Classifications

HY-141486A Related Classifications