TAN-67 dihydrobromide
Based on 1 publication(s) in Google Scholar
TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 1217628-73-3
- Formula: C23H26Br2N2O
- Molecular Weight:506.27
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) TAN-67 dihydrobromide
MoreAll Opioid Receptor Isoforms
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Biological Activity
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δ Opioid Receptor/DOR 0.647 nM (Ki) |
TAN-67 (SB-205607) dihydrobromide has high potency (EC50=1.72 nM) for the inhibition of forskolin-stimulated cAMP accumulation at human delta-opioid receptors expressed by intact Chinese hamster ovary cells but low potency (EC50=1520 nM) at human mu-opioid receptors expressed by intact B82 mouse fibroblast cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide improves survival and neurobehavioral performance after I/R[2].
TAN-67 (3 mg/kg; i.v.; once; adult C57BL/6J male mice) dihydrobromide increases both total APP and mature APP (APPm) levels and APP processing at an early time point (6 h)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult C57BL/6J male mice with I/R-caused brain injury[2]
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Dosage:1.5, 3.0, and 4.5 mg/kg
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Administration:Intravenous injection; once
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Result:Reduced infarct volume in a dose-dependent manner.
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Animal Model:Adult C57BL/6J male mice with I/R-caused brain injury[2]
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Dosage:3.0 mg/kg
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Administration:Intravenous injection; once
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Result:Had rapidly functional recovery than the vehicle-treated mice.
Reduced neuronal cell death.
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Animal Model:Adult C57BL/6J male mice with transient middle cerebra artery occlusion (MCAO) ischemic stroke model[2]
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Dosage:3.0 mg/kg
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Administration:Intravenous injection; once
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Result:Increased both total APP and mature APP (APPm) levels.
Reduced β-secretase activity.
Chemical Information
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CAS No. 1217628-73-3
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Appearance Solid
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Molecular Weight 506.27
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Formula C23H26Br2N2O
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Color White to off-white
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SMILES
OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1.Br.Br
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Synonyms
SB-205607 dihydrobromide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons. [Abstract]2025 Dec 24;188(26):7547-7570.e45 PMID: 41406962
Solvent & Solubility
DMSO : 5 mg/mL (9.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Knapp RJ, et, al. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. Eur J Pharmacol. 1995 Oct 15;291(2):129-34. [Content Brief]
[2]. Min JW, et, al. The non-peptidic δ-opioid receptor agonist Tan-67 mediates neuroprotection post-ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice. J Neurochem. 2018 Feb;144(3):336-347. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9752 mL | 9.8762 mL | 19.7523 mL | 49.3808 mL |
| 5 mM | 0.3950 mL | 1.9752 mL | 3.9505 mL | 9.8762 mL |
TAN-67 dihydrobromide Related Classifications
HY-101317 Related Classifications
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