1. TAN-67 dihydrobromide

TAN-67 dihydrobromide  (Synonyms: SB-205607 dihydrobromide)

Cat. No.: HY-101317 Purity: ≥99.0%
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TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke.

For research use only. We do not sell to patients.

TAN-67 dihydrobromide Chemical Structure

TAN-67 dihydrobromide Chemical Structure

CAS No. : 1217628-73-3

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Description

TAN-67 (SB-205607) dihydrobromide is a potent and selective nonpeptidic δ-opioid receptor agonist with a Ki value of 0.647 nM. TAN-67 dihydrobromide has neuroprotective effect. TAN-67 dihydrobromide can be used in research of ischemic stroke[1][2].

In Vitro

TAN-67 (SB-205607) dihydrobromide has high potency (EC50=1.72 nM) for the inhibition of forskolin-stimulated cAMP accumulation at human delta-opioid receptors expressed by intact Chinese hamster ovary cells but low potency (EC50=1520 nM) at human mu-opioid receptors expressed by intact B82 mouse fibroblast cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TAN-67 (SB-205607; 1.5-4.5 mg/kg; i.v.; once) dihydrobromide reduces infarct volume in I/R-caused brain injury[2].
TAN-67 (3 mg/kg; i.v.; once) dihydrobromide improves survival and neurobehavioral performance after I/R[2].
TAN-67 (3 mg/kg; i.v.; once; adult C57BL/6J male mice) dihydrobromide increases both total APP and mature APP (APPm) levels and APP processing at an early time point (6 h)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 1.5, 3.0, and 4.5 mg/kg
Administration: Intravenous injection; once
Result: Reduced infarct volume in a dose-dependent manner.
Animal Model: Adult C57BL/6J male mice with I/R-caused brain injury[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Had rapidly functional recovery than the vehicle-treated mice.
Reduced neuronal cell death.
Animal Model: Adult C57BL/6J male mice with transient middle cerebra artery occlusion (MCAO) ischemic stroke model[2]
Dosage: 3.0 mg/kg
Administration: Intravenous injection; once
Result: Increased both total APP and mature APP (APPm) levels.
Reduced β-secretase activity.
Molecular Weight

506.27

Formula

C23H26Br2N2O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC([C@]23[C@@](CN(C)CC3)([H])CC4=CC5=CC=CC=C5N=C4C2)=C1.Br.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TAN-67 dihydrobromide
Cat. No.:
HY-101317
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