5'-Guanidinonaltrindole hydrochloride
Based on 1 Customer Validation
5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.06%
- CAS No.: 351183-88-5
- Formule: C27H31Cl2N5O3
- Masse moléculaire:544.47
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
human μ-opioid receptor 36.9 nM (Ki) |
human μ-opioid receptor 8.49 (pA2) |
In Vitro
5'-Guanidinonaltrindole (5'-GNTI) also binds to human μ- and δ-opioid receptors with Kis of 36.9±2.3 nM and 70.0±0.3 nM, respectively[1].
5'-Guanidinonaltrindole is most effective at κ-opioid receptors (pA2=10.4±0.10), with substantially lower antagonist potency at μ-opioid (pA2=8.49±0.09) and δ-opioid receptors (pA2=7.81±0.06)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss-Webster mice[2]
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Dosage:0.03, 0.1, 0.3, 1 and 3 mg/kg
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Administration:Subcutaneous injection, once
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Result:Induced scratching, the scratch A50 value was calculated to be 0.17 mg/kg.
Chemical Information
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CAS No. 351183-88-5
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Appearance Solid
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Masse moléculaire 544.47
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Formule C27H31Cl2N5O3
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Color White to off-white
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SMILES
NC(NC1=CC2=C(NC3=C2C[C@]([C@]4([H])N(CC5CC5)CC6)(O)[C@]76[C@@]3([H])OC8=C(O)C=CC(C4)=C87)C=C1)=N.[H]Cl.[H]Cl
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Synonyms
5'-GNTI hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (229.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (45.92 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8366 mL | 9.1832 mL | 18.3665 mL | 45.9162 mL |
| 5 mM | 0.3673 mL | 1.8366 mL | 3.6733 mL | 9.1832 mL | |
| 10 mM | 0.1837 mL | 0.9183 mL | 1.8366 mL | 4.5916 mL | |
| 15 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0611 mL | |
| 20 mM | 0.0918 mL | 0.4592 mL | 0.9183 mL | 2.2958 mL | |
| 25 mM | 0.0735 mL | 0.3673 mL | 0.7347 mL | 1.8366 mL | |
| 30 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 40 mM | 0.0459 mL | 0.2296 mL | 0.4592 mL | 1.1479 mL | |
| DMSO | 50 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.9183 mL |
| 60 mM | 0.0306 mL | 0.1531 mL | 0.3061 mL | 0.7653 mL | |
| 80 mM | 0.0230 mL | 0.1148 mL | 0.2296 mL | 0.5740 mL | |
| 100 mM | 0.0184 mL | 0.0918 mL | 0.1837 mL | 0.4592 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
5'-Guanidinonaltrindole hydrochloride Related Classifications
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