2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. 5'-Guanidinonaltrindole hydrochloride

5'-Guanidinonaltrindole hydrochloride  (Synonyms: 5'-GNTI hydrochloride)

Cat. No.: HY-107748 Purity: 98.72%
COA Handling Instructions

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5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor.

For research use only. We do not sell to patients.

5'-Guanidinonaltrindole hydrochloride Chemical Structure

5'-Guanidinonaltrindole hydrochloride Chemical Structure

CAS No. : 351183-88-5

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10 mg USD 1136 In-stock
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Based on 1 publication(s) in Google Scholar

5'-Guanidinonaltrindole hydrochloride Related Antibodies

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Description

5'-Guanidinonaltrindole (5'-GNTI) hydrochloride is a highly selective and potent κ-opioid receptor antagonist with a Ki of 0.18 nM for human κ-opioid receptor[1].

IC50 & Target[1]

human μ-opioid receptor

36.9 nM (Ki)

human μ-opioid receptor

8.49 (pA2)

In Vitro

5'-Guanidinonaltrindole (5'-GNTI) also binds to human μ- and δ-opioid receptors with Kis of 36.9±2.3 nM and 70.0±0.3 nM, respectively[1].
5'-Guanidinonaltrindole is most effective at κ-opioid receptors (pA2=10.4±0.10), with substantially lower antagonist potency at μ-opioid (pA2=8.49±0.09) and δ-opioid receptors (pA2=7.81±0.06)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5'-Guanidinonaltrindole hydrochloride Related Antibodies
In Vivo

5'-Guanidinonaltrindole (5'-GNTI) (0.03-3 mg/kg; s.c.; once) induces scratching in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice[2]
Dosage: 0.03, 0.1, 0.3, 1 and 3 mg/kg
Administration: Subcutaneous injection, once
Result: Induced scratching, the scratch A50 value was calculated to be 0.17 mg/kg.
Molecular Weight

544.47

Formula

C27H31Cl2N5O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NC1=CC2=C(NC3=C2C[C@]([C@]4([H])N(CC5CC5)CC6)(O)[C@]76[C@@]3([H])OC8=C(O)C=CC(C4)=C87)C=C1)=N.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (229.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8366 mL 9.1832 mL 18.3665 mL
5 mM 0.3673 mL 1.8366 mL 3.6733 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.72%

COA (256 KB) HNMR (326 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8366 mL 9.1832 mL 18.3665 mL 45.9162 mL
5 mM 0.3673 mL 1.8366 mL 3.6733 mL 9.1832 mL
10 mM 0.1837 mL 0.9183 mL 1.8366 mL 4.5916 mL
15 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0611 mL
20 mM 0.0918 mL 0.4592 mL 0.9183 mL 2.2958 mL
25 mM 0.0735 mL 0.3673 mL 0.7347 mL 1.8366 mL
30 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5305 mL
40 mM 0.0459 mL 0.2296 mL 0.4592 mL 1.1479 mL
50 mM 0.0367 mL 0.1837 mL 0.3673 mL 0.9183 mL
60 mM 0.0306 mL 0.1531 mL 0.3061 mL 0.7653 mL
80 mM 0.0230 mL 0.1148 mL 0.2296 mL 0.5740 mL
100 mM 0.0184 mL 0.0918 mL 0.1837 mL 0.4592 mL
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5'-Guanidinonaltrindole hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5'-Guanidinonaltrindole351183-88-55'-GNTIOpioid Receptorscratchingκ-opioid receptorSwiss-Webster miceInhibitorinhibitorinhibit

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