PARP10/15-IN-2
Based on 1 Customer Validation
PARP10/15-IN-2 (Compound 8h) is a potent PARP10 and PARP15 dual inhibitor with IC50 values of 0.15 µM and 0.37 µM against PARP10 and PARP15, respectively. PARP10/15-IN-2 is able to enter cells and rescue cells from apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 2892064-99-0
- Formula: C15H11FN2O3
- Molecular Weight:286.26
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Epigenetics Compound Library
HY-L005
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Cell Death Library
HY-L162
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Anti-Ovarian Cancer Compound Library
HY-L173
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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PARP10 0.15 μM (IC50) |
PARP15 0.37 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
1.6 μM
Compound: 8h
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Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
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[PMID: 35500474] |
Chemical Information
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CAS No. 2892064-99-0
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Appearance Solid
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Molecular Weight 286.26
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Formula C15H11FN2O3
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Color White to off-white
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SMILES
O=C1NNC(C2=C1C=CC(OCC3=CC=CC=C3F)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 50 mg/mL (174.67 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4933 mL | 17.4666 mL | 34.9333 mL | 87.3332 mL |
| 5 mM | 0.6987 mL | 3.4933 mL | 6.9867 mL | 17.4666 mL | |
| 10 mM | 0.3493 mL | 1.7467 mL | 3.4933 mL | 8.7333 mL | |
| 15 mM | 0.2329 mL | 1.1644 mL | 2.3289 mL | 5.8222 mL | |
| 20 mM | 0.1747 mL | 0.8733 mL | 1.7467 mL | 4.3667 mL | |
| 25 mM | 0.1397 mL | 0.6987 mL | 1.3973 mL | 3.4933 mL | |
| 30 mM | 0.1164 mL | 0.5822 mL | 1.1644 mL | 2.9111 mL | |
| 40 mM | 0.0873 mL | 0.4367 mL | 0.8733 mL | 2.1833 mL | |
| 50 mM | 0.0699 mL | 0.3493 mL | 0.6987 mL | 1.7467 mL | |
| 60 mM | 0.0582 mL | 0.2911 mL | 0.5822 mL | 1.4556 mL | |
| 80 mM | 0.0437 mL | 0.2183 mL | 0.4367 mL | 1.0917 mL | |
| 100 mM | 0.0349 mL | 0.1747 mL | 0.3493 mL | 0.8733 mL |
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