1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. iRucaparib-AP6

iRucaparib-AP6 

Cat. No.: HY-130644 Purity: 98.06%
Handling Instructions

iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1.

For research use only. We do not sell to patients.

iRucaparib-AP6 Chemical Structure

iRucaparib-AP6 Chemical Structure

CAS No. : 2410557-00-3

Size Price Stock Quantity
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1].

In Vitro

iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC50) of 82 nM (Dmax = 92%)[1].
iRucaparib-AP6 (0-20 μM; 24 hours) induces degradation of PARP1 at low concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Primary rat neonatal cardiomyocyte cells
Concentration: 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM
Incubation Time: 24 hours
Result: Decreased PARP-1 level in primary rat neonatal cardiomyocyte cells.

Western Blot Analysis[1]

Cell Line: Primary rat neonatal cardiomyocyte cells
Concentration: 0.05 μM; 0.1 μM; 0.2 μM; 0.5 μM; 1 μM; 2 μM; 5 μM;10 μM; 20 μM
Incubation Time: 24 hours
Result: Induced robust PARP1 degradation at concentrations as low as 50 nM.
Molecular Weight

886.96

Formula

C₄₆H₅₅FN₆O₁₁

CAS No.

2410557-00-3

SMILES

O=C(NCC1)C2=CC(F)=CC3=C2C1=C(C4=CC=C(C=C4)CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)C)N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (56.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1274 mL 5.6372 mL 11.2745 mL
5 mM 0.2255 mL 1.1274 mL 2.2549 mL
10 mM 0.1127 mL 0.5637 mL 1.1274 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.82 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.06%

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Keywords:

iRucaparib-AP6PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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Product Name:
iRucaparib-AP6
Cat. No.:
HY-130644
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