PARP10/15-IN-1
Based on 1 Customer Validation
PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 95.04%
- CAS. Nr.: 2892065-01-7
- Formel: C13H10N2O3S
- Molecular Weight:274.30
-
Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PARP10 160 nM (IC50) |
PARP15 370 nM (IC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
0.95 μM
Compound: 8l
|
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
Rescue of cell viability in human HeLa cells expressing wild type PARP10 at upto 10 uM incubated for 10 to 12 days by methylene blue dye based colony formation assay
|
[PMID: 35500474] |
Chemical Information
-
CAS. Nr. 2892065-01-7
-
Appearance Solid
-
Molecular Weight 274.30
-
Formel C13H10N2O3S
-
Color White to off-white
-
SMILES
O=C1NNC(C2=C1C=CC(OCC3=CSC=C3)=C2)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (91.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6456 mL | 18.2282 mL | 36.4564 mL | 91.1411 mL |
| 5 mM | 0.7291 mL | 3.6456 mL | 7.2913 mL | 18.2282 mL | |
| 10 mM | 0.3646 mL | 1.8228 mL | 3.6456 mL | 9.1141 mL | |
| 15 mM | 0.2430 mL | 1.2152 mL | 2.4304 mL | 6.0761 mL | |
| 20 mM | 0.1823 mL | 0.9114 mL | 1.8228 mL | 4.5571 mL | |
| 25 mM | 0.1458 mL | 0.7291 mL | 1.4583 mL | 3.6456 mL | |
| 30 mM | 0.1215 mL | 0.6076 mL | 1.2152 mL | 3.0380 mL | |
| 40 mM | 0.0911 mL | 0.4557 mL | 0.9114 mL | 2.2785 mL | |
| 50 mM | 0.0729 mL | 0.3646 mL | 0.7291 mL | 1.8228 mL | |
| 60 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5190 mL | |
| 80 mM | 0.0456 mL | 0.2279 mL | 0.4557 mL | 1.1393 mL |
PARP10/15-IN-1 Related Classifications
HY-143398 Related Classifications
Powered by Bioz