VEGFR/PARP-IN-1
VEGFR/PARP-IN-1 (Compound 14b) is a VEGFR/PARP dual inhibitor (IC50s: 191 nM and 60.9 nM respectively). VEGFR/PARP-IN-1 inhibits DNA damage repair, induces cell apoptosis, and arrests cell in the G2/M phase. VEGFR/PARP-IN-1 has good antiproliferative efficacy against BRCA wild-type breast cancer cells (IC50: 4.1 and 3.5 μM for MDA-MB-231 and MCF-7 cells). VEGFR/PARP-IN-1 is an antitumor and anti-metastasis agent.
For research use only. We do not sell to patients.
- CAS No.: 3010256-54-6
- Formula: C29H27N9O
- Molecular Weight:517.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
191 nM and 60.9 nM (VEGFR/PARP)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC1937 | IC50 |
2742 nM
Compound: 14b
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Antiproliferative activity against human HCC1937 cells assessed as cell growth inhibition
Antiproliferative activity against human HCC1937 cells assessed as cell growth inhibition
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[PMID: 37616488] |
| HUVEC | IC50 |
2.2 μM
Compound: 14b
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Inhibition of cell survival in VEGF165-treated HUVEC cells incubated for 48 hrs by CCK8 assay
Inhibition of cell survival in VEGF165-treated HUVEC cells incubated for 48 hrs by CCK8 assay
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[PMID: 37616488] |
| MCF7 | IC50 |
3540 nM
Compound: 14b
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition
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[PMID: 37616488] |
| MDA-MB-231 | IC50 |
4130 nM
Compound: 14b
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition
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[PMID: 37616488] |
| MDA-MB-436 | IC50 |
1906 nM
Compound: 14b
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Antiproliferative activity against human MDA-MB-436 cells assessed as cell growth inhibition
Antiproliferative activity against human MDA-MB-436 cells assessed as cell growth inhibition
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[PMID: 37616488] |
Chemical Information
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CAS No. 3010256-54-6
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Molecular Weight 517.58
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Formula C29H27N9O
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SMILES
NC(C1=CC=CC2=C1N=C(N2)C3=C(C=CC(NC4=NC=CC(N(C)C5=CC6=NN(C(C)=C6C=C5)C)=N4)=C3)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR/PARP-IN-1 Related Classifications
HY-155965 Related Classifications
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