2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. Amelparib hydrochloride

Amelparib hydrochloride  (Synonyms: JPI-289 hydrochloride)

Cat. No.: HY-116218C Purity: 98.37%
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Amelparib (JPI-289) hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib hydrochloride inhibits PARP-1 activity (IC50 = 18.5 nM) and cellular PAR formation (IC50 = 10.7 nM). Amelparib hydrochloride is a potential neuroprotective agent. Amelparib hydrochloride has the potential for the research of acute ischaemic stroke.

For research use only. We do not sell to patients.

Amelparib hydrochloride Chemical Structure

Amelparib hydrochloride Chemical Structure

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1 mg USD 490 In-stock
5 mg USD 1230 In-stock
10 mg USD 1980 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Amelparib (JPI-289) hydrochloride is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib hydrochloride inhibits PARP-1 activity (IC50 = 18.5 nM) and cellular PAR formation (IC50 = 10.7 nM). Amelparib hydrochloride is a potential neuroprotective agent. Amelparib hydrochloride has the potential for the research of acute ischaemic stroke[1].

Molecular Weight

379.88

Formula

C19H26ClN3O3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1NC2=C(C3=C1CCCN3)C(OCC)=CC(CN4CCOCC4)=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Amelparib hydrochloride Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AmelparibJPI-289JPI289JPI 289PARPpoly ADP ribose polymeraseoralwater-solublePARP-1PAR formationneuroprotectiveacute ischaemic strokeInhibitorinhibitorinhibit

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