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    Apoptosis
  2. Androgen Receptor
    Apoptosis
  3. CSRM617

CSRM617 

Cat. No.: HY-122611
Handling Instructions

CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model

For research use only. We do not sell to patients.

CSRM617 Chemical Structure

CSRM617 Chemical Structure

CAS No. : 787504-88-5

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Description

CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model[1]

In Vitro

CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].
CSRM617 (10-20 μM; 48 hours) induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].
CSRM617 (20 μM; 72 hours) induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].

Molecular Weight

255.23

Formula

C₁₀H₁₃N₃O₅

CAS No.

787504-88-5

SMILES

N[[email protected]@H](CO)C(N/N=C/C1=CC=C(O)C(O)=C1O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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