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  3. CSRM617 hydrochloride

CSRM617 hydrochloride 

Cat. No.: HY-122611A Purity: ≥99.0%
Handling Instructions

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

For research use only. We do not sell to patients.

CSRM617 hydrochloride Chemical Structure

CSRM617 hydrochloride Chemical Structure

CAS No. : 1353749-74-2

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5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]

In Vitro

CSRM617 (0.01-100 μM; 48 hours) hydrochloride inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].
CSRM617 (10-20 μM; 48 hours) hydrochloride induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].
CSRM617 (20 μM; 72 hours) hydrochloride induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CSRM617 (50 mg/kg; p.o.; daily, for 20 d) inhibits tumor growth in SCID mice with 22Rv1 xenograft[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with 22Rv1 xenograft[1]
Dosage: 50 mg/kg
Administration: Oral administration; daily, for 20 days
Result: Elicited a significant reduction in the onset and growth of diffuse metastases.
Molecular Weight

291.69

Formula

C10H14ClN3O5

CAS No.
SMILES

O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥99.0%

References
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Product Name:
CSRM617 hydrochloride
Cat. No.:
HY-122611A
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