1. Vitamin D Related/Nuclear Receptor Apoptosis
  2. Androgen Receptor Apoptosis
  3. CSRM617 hydrochloride

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model

For research use only. We do not sell to patients.

CSRM617 hydrochloride Chemical Structure

CSRM617 hydrochloride Chemical Structure

CAS No. : 1353749-74-2

Size Price Stock Quantity
5 mg USD 85 In-stock
10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CSRM617 hydrochloride:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE CSRM617 hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]

In Vitro

CSRM617 (0.01-100 μM; 48 hours) hydrochloride inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells[1].
CSRM617 (10-20 μM; 48 hours) hydrochloride induces apoptosis in 22Rv1 cells results in cell death in a concentration-dependent fashion[1].
CSRM617 (20 μM; 72 hours) hydrochloride induces apoptosis in 22Rv1 cells by appearance of cleaved Caspase-3 and PARP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CSRM617 (50 mg/kg; p.o.; daily, for 20 d) inhibits tumor growth in SCID mice with 22Rv1 xenograft[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with 22Rv1 xenograft[1]
Dosage: 50 mg/kg
Administration: Oral administration; daily, for 20 days
Result: Elicited a significant reduction in the onset and growth of diffuse metastases.
Molecular Weight

291.69

Formula

C10H14ClN3O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (428.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4283 mL 17.1415 mL 34.2830 mL
5 mM 0.6857 mL 3.4283 mL 6.8566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4283 mL 17.1415 mL 34.2830 mL 85.7074 mL
5 mM 0.6857 mL 3.4283 mL 6.8566 mL 17.1415 mL
10 mM 0.3428 mL 1.7141 mL 3.4283 mL 8.5707 mL
15 mM 0.2286 mL 1.1428 mL 2.2855 mL 5.7138 mL
20 mM 0.1714 mL 0.8571 mL 1.7141 mL 4.2854 mL
25 mM 0.1371 mL 0.6857 mL 1.3713 mL 3.4283 mL
30 mM 0.1143 mL 0.5714 mL 1.1428 mL 2.8569 mL
40 mM 0.0857 mL 0.4285 mL 0.8571 mL 2.1427 mL
50 mM 0.0686 mL 0.3428 mL 0.6857 mL 1.7141 mL
60 mM 0.0571 mL 0.2857 mL 0.5714 mL 1.4285 mL
80 mM 0.0429 mL 0.2143 mL 0.4285 mL 1.0713 mL
100 mM 0.0343 mL 0.1714 mL 0.3428 mL 0.8571 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CSRM617 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CSRM617 hydrochloride
Cat. No.:
HY-122611A
Quantity:
MCE Japan Authorized Agent: