1353749-74-2
Chemical Structure
CSRM617 hydrochloride
- CAS No.: 1353749-74-2
- Formula:C10H14ClN3O5
- Molecular Weight:291.69
IUPAC Name: (E)-2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride
InChIKey: YBUPSOQAGSOATG-QXKVDVGOSA-N
SMILES: O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl
Biological Activity: CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]
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CSRM617 hydrochloride | 99.97% | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model | ||||||||||||||||||||
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Keywords
