PARP-1/2-IN-2
PARP-1/2-IN-2-IN-1 (Compound 12e) is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). PARP-1/2-IN-2 inhibits DNA damage repair, promotes cell cycle arrest and apoptosis. PARP-1/2-IN-2 inhibits the growth of TNBC cells and TNBC xenograft tumor.
For research use only. We do not sell to patients.
- CAS No.: 3052304-23-8
- Formula: C25H23IN8O3
- Molecular Weight:610.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
8.5 μM
Compound: 12e
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
|
[PMID: 37478560] |
| MDA-MB-436 | IC50 |
9 μM
Compound: 12e
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Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-436 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
|
[PMID: 37478560] |
| MDA-MB-468 | IC50 |
9.7 μM
Compound: 12e
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Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth incubated for 24 hrs by MTT assay
|
[PMID: 37478560] |
Chemical Information
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CAS No. 3052304-23-8
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Molecular Weight 610.41
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Formula C25H23IN8O3
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SMILES
NC(C1=CC=CC2=C1N=C(NC(C3=CC(C(N4CCC(NC5=NC=C(I)C=N5)CC4)=O)=CC=C3)=O)N2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP-1/2-IN-2 Related Classifications
HY-149398 Related Classifications
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