1. PROTAC
    Cell Cycle/DNA Damage
    Epigenetics
  2. E3 Ligase Ligand-Linker Conjugate
    PARP
  3. N-Descyclopropanecarbaldehyde Olaparib

N-Descyclopropanecarbaldehyde Olaparib 

Cat. No.: HY-75706
Handling Instructions

N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor.

For research use only. We do not sell to patients.

N-Descyclopropanecarbaldehyde Olaparib Chemical Structure

N-Descyclopropanecarbaldehyde Olaparib Chemical Structure

CAS No. : 763111-47-3

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
250 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor[2].

IC50 & Target[1]

Cereblon

 

Molecular Weight

366.39

Formula

C₂₀H₁₉FN₄O₂

CAS No.
SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CCNCC3)=O)=C2)C4=C1C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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Keywords:

N-Descyclopropanecarbaldehyde OlaparibE3 Ligase Ligand-Linker ConjugatePARPpoly ADP ribose polymerasetheranostic agentovarian cancerPETimagingtumorpositron emission tomographyprotacligandEGFRInhibitorinhibitorinhibit

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Product Name:
N-Descyclopropanecarbaldehyde Olaparib
Cat. No.:
HY-75706
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