1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

ME0328 

Cat. No.: HY-100225 Purity: 99.34%
Handling Instructions

ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM.

For research use only. We do not sell to patients.

ME0328 Chemical Structure

ME0328 Chemical Structure

CAS No. : 1445251-22-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
25 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 340 In-stock
Estimated Time of Arrival: December 31
100 mg USD 610 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM.

IC50 & Target[1]

ARTD3/PARP3

0.89 μM (IC50)

ARTD1/PARP1

6.3 μM (IC50)

ARTD2/PARP2

10.8 μM (IC50)

ARTD6/TNKS2

34.3 μM (IC50)

ARTD5/TNKS1

47.3 μM (IC50)

ARTD10/PARP10

71.3 μM (IC50)

In Vitro

ME0328 is a potent and selective inhibitor of ARTD3/PARP3 that is active in cells. In in vitro histone H1 modification assay, ME0328 inhibits the transferase activity of ARTD3 with an IC50 of 0.89±0.28 μM. In human A549 cells, ME0328 and ME0355 (at 10 μM) delay the resolution of γH2AX-containing foci that serve as markers for DNA double strand break repair following γ-irradiation (2 Gy). In silico and in vitro physicochemical and metabolic profiling indicated that ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes[1].

Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (233.38 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1117 mL 15.5584 mL 31.1168 mL
5 mM 0.6223 mL 3.1117 mL 6.2234 mL
10 mM 0.3112 mL 1.5558 mL 3.1117 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.78 mM); Clear solution

References
Molecular Weight

321.37

Formula

C₁₉H₁₉N₃O₂

CAS No.

1445251-22-8

SMILES

O=C(N[[email protected]](C1=CC=CC=C1)C)CCC(NC2=C3C=CC=C2)=NC3=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ME0328
Cat. No.:
HY-100225
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ME0328

Cat. No.: HY-100225