1. PROTAC
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
    Epigenetics
    Cell Cycle/DNA Damage
  2. PROTAC
    EGFR
    PARP
  3. DP-C-4

DP-C-4 

Cat. No.: HY-141481
Handling Instructions

DP-C-4 is a CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP.

For research use only. We do not sell to patients.

DP-C-4 Chemical Structure

DP-C-4 Chemical Structure

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Description

DP-C-4 is a CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].

IC50 & Target[1]

Cereblon

 

In Vitro

DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: SW1990 cells
Concentration: 1 μM, 3 μM, 5 μM, 10 μM, 30 μM, 50 μM
Incubation Time: 24 hours
Result: Had degradation effects on EGFR and PARP simultaneously in SW1990 cells.
Molecular Weight

1450.93

Formula

C₇₂H₇₈ClF₂N₁₅O₁₄

SMILES

O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(CCCCCNC(C(NC(CCCCCOC4=C(OC)C=C(N=CN=C5NC6=CC=C(F)C(Cl)=C6)C5=C4)=O)COCC7=CN(CCOCCOCCNC8=CC=CC(C(N9C%10CCC(NC%10=O)=O)=O)=C8C9=O)N=N7)=O)=O)CC3)=O)=C2)C%11=C1C=CC=C%11

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DP-C-4PROTACEGFRPARPProteolysis-targeting chimeraEpidermal growth factor receptorErbB-1HER1poly ADP ribose polymeraseCRBNE3ligandsdegradationInhibitorinhibitorinhibit

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DP-C-4
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