1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. NU1025

NU1025 

Cat. No.: HY-15044
Handling Instructions

NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity.

For research use only. We do not sell to patients.

NU1025 Chemical Structure

NU1025 Chemical Structure

CAS No. : 90417-38-2

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Description

NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer drugs. NU1025 has anti-cancer and neuroprotective activity[1][2][3].

IC50 & Target

IC50: 400 nM (PARP)[2]
Ki: 48 nM (PARP)[3]

In Vitro

NU1025 (0.2 mM) pretreatment restores cell viability to approximately 73% and 82% in H2O2 and SIN-1 injured cells, respectively[1].
NU1025 enhances the cytotoxicity of the DNA-methylating agent MTIC, γ-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively in L1210 cells. The recovery from potentially lethal γ-irradiation damage cytotoxicity in plateau-phase cells is also inhibited by NU 1025. NU1025 causes a marked retardation of DNA repair[2].

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 0.2 mM
Incubation Time: 6.5 hours
Result: Restored cell viability to approximately 73% and 82% in H2O2 and SIN-1 injured cells.
In Vivo

NU1025 (1-3 mg/kg; intraperitoneal injection; male Sprague Dawley rats) treatment at 1 and 3 mg/kg reduces total infarct volume to 25% and 45%, respectively, when administered 1 h before reperfusion. NU1025 also produces significant improvement in neurological deficits. Neuroprotection with NU1025 is associated with reduction in PAR accumulation, reversal of brain NAD depletion and reduction in DNA fragmentation[1].

Animal Model: Male Sprague Dawley rats (250-270 g) induced focal cerebral ischemia[1]
Dosage: 1 mg/kg, 3 mg/kg
Administration: Intraperitoneal injection
Result: At 1 and 3 mg/kg, reduced total infarct volume to 25% and 45%, respectively.
Molecular Weight

176.17

Formula

C₉H₈N₂O₂

CAS No.

90417-38-2

SMILES

OC1=C(N=C(C)NC2=O)C2=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NU1025NU 1025NU-1025PARPpoly ADP ribose polymeraseNeuroprotectivecytotoxicityanti-cancerDNArepairNADPARInhibitorinhibitorinhibit

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