MARCO Protein, Human (HEK293, His)
MARCO Protein, a pattern recognition receptor (PRR), binds both Gram-positive and Gram-negative bacteria, facilitating unopsonized particle binding by alveolar macrophages. It also interacts with the secretoglobin SCGB3A2. Forming disulfide-linked homotrimer structures, MARCO Protein's trimers assemble into larger oligomers, providing an expansive surface area for interactions with substantial ligands. MARCO Protein, Human (HEK293, His) is the recombinant human-derived MARCO protein, expressed by HEK293 , with N-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
MARCO Protein, a pattern recognition receptor (PRR), binds both Gram-positive and Gram-negative bacteria, facilitating unopsonized particle binding by alveolar macrophages. It also interacts with the secretoglobin SCGB3A2. Forming disulfide-linked homotrimer structures, MARCO Protein's trimers assemble into larger oligomers, providing an expansive surface area for interactions with substantial ligands. MARCO Protein, Human (HEK293, His) is the recombinant human-derived MARCO protein, expressed by HEK293 , with N-His labeled tag.
Background
MARCO Protein is a pattern recognition receptor (PRR) that can bind both Gram-positive and Gram-negative bacteria. It also plays a role in binding unopsonized particles by alveolar macrophages. Additionally, MARCO Protein is capable of binding to the secretoglobin SCGB3A2. It forms a homotrimer structure that is disulfide-linked, and these trimers can assemble into larger oligomers, creating a large surface area suitable for interacting with very large ligands.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-8*His
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Accession
Q9UEW3 (S405-V520)
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Molecular Construction
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N-term
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8*His
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MARCO (S405-V520)
Accession # Q9UEW3 -
C-term
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Protein Length
Partial Extracellular Domain
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Synonyms
MARCO; Scavenger Receptor Class A, Member 2; Macrophage Receptor With Collagenous Structure; Macrophage Receptor MARCO; SCARA2; Scavenger Receptor Class A Member 2; SR-A6; Macrophage Receptor
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AA Sequence
SGEQGVKGEKGERGENSVSVRIVGSSNRGRAEVYYSGTWGTICDDEWQNSDAIVFCRMLGYSKGRALYKVGAGTGQIWLDNVQCRGTESTLWSCTKNSWGHHDCSHEEDAGVECSV
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Predicted Molecular Mass
13.8 kDa
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Molecular Weight
Approximately 14-20 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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