2. Gene
  3. MARCO - macrophage receptor with collagenous structure Gene

MARCO - macrophage receptor with collagenous structure Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SR-A6; SCARA2

Gene ID: 8685 | Gene type: protein coding

About MARCO

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:118,942,194-118,994,660 (from NCBI)

This gene has 3 transcripts (splice variants), 150 orthologues and 3 paralogues. Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues.

Summary

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

MARCO Products(1)

mRNA Protein Name
NM_006770.4 NP_006761.1 macrophage receptor MARCO

MARCO Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (148 - 205)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (193 - 235)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (244 - 302)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (361 - 419)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (429 - 519)

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  • 520 a.a.
Protein Preferred Names Protein Names

macrophage receptor MARCO

scavenger receptor class A, member 2

Recombinant MARCO Proteins

Cat. No. Product Name Accession Purity
HY-P78004 MARCO Protein, Human (HEK293, His) Q9UEW3 (S405-V520) ≥95%

Related Diseases

Diseases Alias
Waterhouse-Friderichsen Syndrome

Fatal Pneumococcal Waterhouse-Friderichsen Syndrome

Meningococcal Hemorrhagic Adrenalitis

Waterhouse-Friderichsen Syndrome, Meningococcal

Meningococcal Haemorrhagic Adrenalitis

Meningococcal Adrenal Syndrome

Acute Adrenal Insufficiency With Meningococcal Septicaemia

Adrenal Haemorrhage Syndrome

Waterhouse-Friderichsen Disease

Meningococcal Waterhouse-Friderichsen Syndrome

Haemorrhagic Meningococcal Adrenitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08147 MARCO Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MARCO VGNC VGNC:68183
Mus musculus MARCO MGD MGI:1309998
Canis familiaris MARCO VGNC VGNC:54807
Macaca mulatta MARCO VGNC VGNC:99380
Rattus norvegicus MARCO RGD RGD:1589662
Bos taurus MARCO VGNC VGNC:31246
Others MARCO NCBI