APOA1BP Protein, Human (HEK293, His)

APOA1BP protein plays a crucial role in cellular processes by catalyzing the S- and R-type epimerization of NAD(P)HX, a protein that results from enzymatic or heat-dependent hydration. Damaged form of NAD(P)H. This catalytic activity is a prerequisite for the subsequent action of S-specific NAD(P)H hydrate dehydratase, enabling the repair of both epimers of NAD(P)HX. APOA1BP Protein, Human (HEK293, His) is the recombinant human-derived APOA1BP protein, expressed by HEK293 , with C-His labeled tag. The total length of APOA1BP Protein, Human (HEK293, His) is 288 a.a., with molecular weight of ~30.6 KDa.

APOA1BP, also known as NAXE (NAD(P)HX epimerase), catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H resulting from enzymatic or heat-dependent hydration. This epimerization process is a prerequisite for the subsequent repair by the S-specific NAD(P)H-hydrate dehydratase, allowing the restoration of both epimers of NAD(P)HX. Beyond its role in nucleotide metabolism, APOA1BP plays a role in cholesterol homeostasis by accelerating cholesterol efflux from endothelial cells to high-density lipoprotein (HDL). This function suggests a regulatory role for APOA1BP in angiogenesis, linking its enzymatic activity to processes involved in blood vessel formation. It has to underscore APOA1BP's dual functions in nucleotide metabolism and cholesterol homeostasis, emphasizing its potential impact on cellular processes associated with angiogenesis.

Human

HEK293

C-His

Q8NCW5 (M1-Q288)

128240  [NCBI]

Approximately 30.6 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.