FGFR2-IN-3
Based on 1 Customer Validation
FGFR2-IN-3 is an inhibitor of fibroblast growth factor receptor 2 (FGFR2). FGFR2-IN-3 has good binding properties, forming key interactions and inducing conformational changes in FGFR2. FGFR2-IN-3 can be used for research on tumors.
For research use only. We do not sell to patients.
- Purity: 98.28%
- CAS No.: 389629-38-3
- Formula: C28H22FN5O3
- Molecular Weight:495.50
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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FGFR2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | CC50 |
11 μM
Compound: 18
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Cytotoxicity against human HeLa CD4+ CCR5+ cells after 6 days by XTT assay
Cytotoxicity against human HeLa CD4+ CCR5+ cells after 6 days by XTT assay
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[PMID: 23200249] |
Chemical Information
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CAS No. 389629-38-3
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Appearance Solid
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Molecular Weight 495.50
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Formula C28H22FN5O3
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Color Off-white to yellow
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SMILES
O=C(C1=CNC2=C1C(F)=CC=C2C3=NC4=CC=CC=C4N3)C(N5CCN(C(C6=CC=CC=C6)=O)CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 33.33 mg/mL (67.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0182 mL | 10.0908 mL | 20.1816 mL | 50.4541 mL |
| 5 mM | 0.4036 mL | 2.0182 mL | 4.0363 mL | 10.0908 mL | |
| 10 mM | 0.2018 mL | 1.0091 mL | 2.0182 mL | 5.0454 mL | |
| 15 mM | 0.1345 mL | 0.6727 mL | 1.3454 mL | 3.3636 mL | |
| 20 mM | 0.1009 mL | 0.5045 mL | 1.0091 mL | 2.5227 mL | |
| 25 mM | 0.0807 mL | 0.4036 mL | 0.8073 mL | 2.0182 mL | |
| 30 mM | 0.0673 mL | 0.3364 mL | 0.6727 mL | 1.6818 mL | |
| 40 mM | 0.0505 mL | 0.2523 mL | 0.5045 mL | 1.2614 mL | |
| 50 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.0091 mL | |
| 60 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8409 mL |
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