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Cat. No.: HY-10885

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A-620223 succinate

(Synonyms: ABT-472)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

A-620223 succinate (ABT-472) is an orally available poly(ADP-ribose) polymerase (PARP) inhibitor. A-620223 succinate (ABT-472) exhibits very good potency against the PARP-1 enzyme with a K_i value of 8 nM and an EC₅₀ value of 3 nM in whole cell assay, making it useful in cancer research.

For research use only. We do not sell to patients.

CAS No.: 943650-25-7
Formula: C₂₀H₂₈N₄O₅
Molecular Weight:404.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

A-620223 succinate Chemical Structure

CAS No.: 943650-25-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All PARP Isoforms :

Chemical Information

CAS No. 943650-25-7
Molecular Weight 404.46
Formula C₂₀H₂₈N₄O₅
SMILES

CCCN(CC1)CCC1C2=NC3=C(C(N)=O)C=CC=C3N2.O=C(O)CCC(O)=O
Synonyms

ABT-472
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2025 Nov 10.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Penning TD, et al. Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. Bioorg Med Chem. 2008 Jul 15;16(14):6965-75. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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A-620223 succinate

1 Cited Publications

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A-620223 succinate

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All PARP Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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A-620223 succinate Related Classifications

HY-10885 Related Classifications