2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-11

Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC50 value of 3.4 µM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP.

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Tubulin polymerization-IN-11 Chemical Structure

Tubulin polymerization-IN-11 Chemical Structure

CAS No. : 2470063-59-1

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Tubulin polymerization-IN-11 Related Antibodies

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Description

Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC50 value of 3.4 µM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP[1].

In Vitro

Tubulin polymerization-IN-11 (compound 7i) (0-100 µM; 48 h) shows antiproliferative activity with IC50s of 0.012, >100, 10.40, 40.40, 27.91 µM for HeLa, HEK-293, A549, MCF-7, T47D cells, respectively[1].
Tubulin polymerization-IN-11 (12, 24, 48 nM; 24 h) induces apoptosis and cell cycle arrest at G2/M phase in a dose-dependent manner[1].
Tubulin polymerization-IN-11 (12, 24, 48 nM; 24 h) decreases the expression of cyclin B1, p-cdc2, Bcl-2 protein levels and increases the expression of cleaved PARP in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HeLa, HEK-293, A549, MCF-7, T47D cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 0.012, >100, 10.40, 40.40, 27.91 µM for HeLa, HEK-293, A549, MCF-7, T47D cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HeLa cells
Concentration: 12, 24, 48 nM
Incubation Time: 24 h
Result: Induced cell cycle arrest at G2/M phase with the percentage of cells was 13.90%, 26.00%, and 92.65% at 12, 24, 48 nM, respectively.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 12, 24, 48 nM
Incubation Time: 24 h
Result: Concentration-dependently decreased cyclin B1 and p-cdc2 protein levels.

Apoptosis Analysis[1]

Cell Line: HeLa cells
Concentration: 12, 24, 48 nM
Incubation Time: 24 h
Result: Induced apoptosis with the total numbers of early and late apoptotic cells were 8.44%, 26.87% and 53.3% at 12, 24, and 48 nM, respectively.
Molecular Weight

406.43

Formula

C22H22N4O4
CAS No.
SMILES

COC1=CC=C(C=C1N)C2=CN3C(C=C2)=NN=C3C4=CC(OC)=C(C(OC)=C4)OC
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References
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Tubulin polymerization-IN-11 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Tubulin polymerization-IN-112470063-59-1Microtubule/TubulinApoptosisapoptosisG2/M phaseHeLa cellscyclin B1p-cdc2cleaved PARPInhibitorinhibitorinhibit

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