2470063-59-1
Chemical Structure
Tubulin polymerization-IN-11
- CAS No.: 2470063-59-1
- Formula:C22H22N4O4
- Molecular Weight:406.43
IUPAC Name: 2-methoxy-5-(3-(3,4,5-trimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)aniline
InChIKey: UHDXUJRRMFTWMJ-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1N)C2=CN3C(C=C2)=NN=C3C4=CC(OC)=C(C(OC)=C4)OC
Biological Activity: Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC50 value of 3.4 μM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP[1].
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Tubulin polymerization-IN-11 | Tubulin polymerization-IN-11 is a potent tubulin polymerization inhibitor with an IC50 value of 3.4 μM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP. | |||||||||||||||||||||
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Keywords
