1. Metabolic Enzyme/Protease
    Epigenetics
    Cell Cycle/DNA Damage
  2. Endogenous Metabolite
    PARP
  3. Benzamide

Benzamide (Synonyms: Benzenecarboxamide; Phenylamide)

Cat. No.: HY-Z0283 Purity: 98.27%
Handling Instructions

Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.

For research use only. We do not sell to patients.

Benzamide Chemical Structure

Benzamide Chemical Structure

CAS No. : 55-21-0

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions[1].
Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg)[1]
Dosage: 160 mg/kg
Administration: IP, 2 injection by a 4 h interval
Result: Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment.
Animal Model: C57B1/6N mice[1]
Dosage: 160 mg/kg
Administration: IP, single dosage
Result: Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.
Molecular Weight

121.14

Formula

C7H7NO

CAS No.
SMILES

NC(C1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (990.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.2549 mL 41.2746 mL 82.5491 mL
5 mM 1.6510 mL 8.2549 mL 16.5098 mL
10 mM 0.8255 mL 4.1275 mL 8.2549 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Benzamide
Cat. No.:
HY-Z0283
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