2. Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage
  3. Endogenous Metabolite PARP
  4. Benzamide

Benzamide  (Synonyms: Benzenecarboxamide; Phenylamide)

Cat. No.: HY-Z0283 Purity: 98.27%
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Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature.

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Benzamide Chemical Structure

Benzamide Chemical Structure

CAS No. : 55-21-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Benzamide:

Benzamide Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Benzamide (160 mg/kg; IP, 2 injection by a 4 h interval) attenuates the METH-induced dopamine depletions[1].
Benzamide (160 mg/kg; IP, single dosage) has no acute effect on striatal dopamine metabolism and does not reduce body temperature[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57B1/6N mice (intraperitoneal injection of METH at 2-h intervals; 4 injections of 5 mg/kg, 4 injections of 10 mg/kg, or 2 injections of 20 mg/kg)[1]
Dosage: 160 mg/kg
Administration: IP, 2 injection by a 4 h interval
Result: Partially and significantly attenuated the METH-induced dopamine depletions during the different METH treatment.
Animal Model: C57B1/6N mice[1]
Dosage: 160 mg/kg
Administration: IP, single dosage
Result: Had no acute effect on striatal dopamine metabolism and did not reduce body temperature.
Molecular Weight

121.14

Appearance

Solid

Formula

C7H7NO
CAS No.
SMILES

NC(C1=CC=CC=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (990.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.2549 mL 41.2746 mL 82.5491 mL
5 mM 1.6510 mL 8.2549 mL 16.5098 mL
10 mM 0.8255 mL 4.1275 mL 8.2549 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (24.76 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Benzamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Benzamide55-21-0Benzenecarboxamide PhenylamideEndogenous MetabolitePARPpoly ADP ribose polymeraseMethamphetaminedopamineneuroprotectiveneurotoxicityInhibitorinhibitorinhibit

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