1. Epigenetics
  2. Epigenetic Reader Domain
  3. MT1

MT1 

Cat. No.: HY-111976
Handling Instructions

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1).

For research use only. We do not sell to patients.

MT1 Chemical Structure

MT1 Chemical Structure

CAS No. : 2060573-82-0

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Description

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

In Vitro

MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1].

Western Blot Analysis[1]

Cell Line: MV4;11 cells[1].
Concentration: 100 nM.
Incubation Time: 24 h.
Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
In Vivo

MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].
MT1 exhibits terminal t1/2 of 2.70 h in mice[1].

Animal Model: Leukemia xenograft models[1].
Dosage: 44.2 and 22.1 µmol/kg.
Administration: Intraperitoneally for 14 subsequent days.
Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.
Molecular Weight

1134.20

Formula

C₅₄H₆₆Cl₂N₁₀O₉S₂

CAS No.

2060573-82-0

SMILES

CC1=NN=C2N1C3=C(C(C4=CC=C(C=C4)Cl)=N[[email protected]]2CC(NCCOCCOCCOCCOCCOCCOCCOCCNC(C[C@@H]5N=C(C6=C(N7C5=NN=C7C)SC(C)=C6C)C8=CC=C(C=C8)Cl)=O)=O)C(C)=C(C)S3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MT1MT 1MT-1Epigenetic Reader Domaincaspase-3PARPleukemiaJQ1Inhibitorinhibitorinhibit

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