1. Epigenetics
  2. Epigenetic Reader Domain
  3. MT1

MT1 

Cat. No.: HY-111976
Handling Instructions

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1).

For research use only. We do not sell to patients.

MT1 Chemical Structure

MT1 Chemical Structure

CAS No. : 2060573-82-0

Size Price Stock Quantity
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

In Vitro

MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MV4;11 cells[1].
Concentration: 100 nM.
Incubation Time: 24 h.
Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
In Vivo

MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1].
MT1 exhibits terminal t1/2 of 2.70 h in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Leukemia xenograft models[1].
Dosage: 44.2 and 22.1 µmol/kg.
Administration: Intraperitoneally for 14 subsequent days.
Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.
Molecular Weight

1134.20

Formula

C₅₄H₆₆Cl₂N₁₀O₉S₂

CAS No.

2060573-82-0

SMILES

CC1=NN=C2N1C3=C(C(C4=CC=C(C=C4)Cl)=N[[email protected]]2CC(NCCOCCOCCOCCOCCOCCOCCOCCNC(C[[email protected]@H]5N=C(C6=C(N7C5=NN=C7C)SC(C)=C6C)C8=CC=C(C=C8)Cl)=O)=O)C(C)=C(C)S3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (132.25 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8817 mL 4.4084 mL 8.8168 mL
5 mM 0.1763 mL 0.8817 mL 1.7634 mL
10 mM 0.0882 mL 0.4408 mL 0.8817 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (6.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 7.5 mg/mL (6.61 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (6.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MT1MT 1MT-1Epigenetic Reader Domaincaspase-3PARPleukemiaJQ1Inhibitorinhibitorinhibit

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MT1
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HY-111976
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