1. Anti-infection
  2. HIV
    Reverse Transcriptase
  3. Nigranoic acid

Nigranoic acid 

Cat. No.: HY-122935
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Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.

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Nigranoic acid Chemical Structure

Nigranoic acid Chemical Structure

CAS No. : 39111-07-4

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Description

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model[1][2].

IC50 & Target

HIV-1 reverse transcriptase

In Vivo

Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation[2].
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].

Animal Model: Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2]
Dosage: 1 mg/kg
Administration: Intragastric; 6 hours and 2 hours before brain ischemia
Result: Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
Molecular Weight

470.68

Formula

C₃₀H₄₆O₄

CAS No.

39111-07-4

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Keywords:

Nigranoic acidHIVReverse TranscriptaseHuman immunodeficiency virusHIV-1reversetranscriptaseischemia-reperfusionInhibitorinhibitorinhibit

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