Nigranoic acid
Based on 1 Customer Validation
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 39111-07-4
- Formula: C30H46O4
- Molecular Weight:470.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HIV-1 reverse transcriptase
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C8166 | CC50 |
88 μg/mL
Compound: 3
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Cytotoxicity against human C8166 cells by MTT assay
Cytotoxicity against human C8166 cells by MTT assay
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[PMID: 16499331] |
| C8166 | EC50 |
10.3 μg/mL
Compound: 3
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Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of viral-induced cytopathic effect
Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of viral-induced cytopathic effect
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[PMID: 16499331] |
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model[2]
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Dosage:1 mg/kg
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Administration:Intragastric; 6 hours and 2 hours before brain ischemia
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Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
Chemical Information
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CAS No. 39111-07-4
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Appearance Solid
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Molecular Weight 470.68
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Formula C30H46O4
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Color Off-white to light yellow
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SMILES
OC(CC[C@@]12[C@]3([C@](CC[C@H]2C(C)=C)([H])[C@]4([C@@](C)([C@]([C@H](C)CC/C=C(C)\C(O)=O)([H])CC4)CC3)C)C1)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Sun HD, et al. Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod. 1996 May;59(5):525-7. [Content Brief]
[2]. Feng T, et al. Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway. Cell Biochem Biophys. 2015 Jan;71(1):345-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nigranoic acid Related Classifications
HY-122935 Related Classifications
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