Nigranoic acid, a triterpenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase

  • J Nat Prod. 1996 May;59(5):525-7. doi: 10.1021/np960149h.
H D Sun  1 ,  S X Qiu ,  L Z Lin ,  Z Y Wang ,  Z W Lin ,  T Pengsuparp ,  J M Pezzuto ,  H H Fong ,  G A Cordell ,  N R Farnsworth
Affiliations
  • 1. Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan, People's Republic of China.
PMID: 8778243 DOI: 10.1021/np960149h
Abstract

An A ring-secocycloartene triterpenoid, nigranoic acid (3,4-secocycloarta-4(28),24-(Z)-diene-3,-26-dioic acid, (1) was isolated from the stems of Schisandra sphaerandra, a Chinese traditional medicinal plant. Its structure elucidation and unambiguous NMR spectral assignment were achieved by the combination of 1D- and 2D-NMR techniques with the aid of computer modeling. Nigranoic acid showed activity in several anti-HIV Reverse Transcriptase and polymerase assays.

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