1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. DNMDP

DNMDP 

Cat. No.: HY-W028690
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DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity.

For research use only. We do not sell to patients.

DNMDP Chemical Structure

DNMDP Chemical Structure

CAS No. : 328104-79-6

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Description

DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity[1].

In Vitro

DNMDP (0-1000 μM; 48 hours) shows clear cell-selective cytotoxicity[1].
HeLa cells undergo apoptosis upon DNMDP treatment, indicates by caspase activity detected by a caspase-sensitive luciferase assay and by poly ADP ribose polymerase (PARP) cleavage. At a concentration of 100 nM, DNMDP specifically inhibits both PDE3A and PDE3B, weakly inhibits PDE10, and had little or no detectable effect on other phosphodiesterases[1].

Cell Viability Assay[1]

Cell Line: NCI-H1563, NCI-H2122, HeLa, A549, MCF7, and PC3 cells
Concentration: 0-1000 μM
Incubation Time: 48 hours
Result: Showed an EC50 between 10 and 100 nM for two additional lung adenocarcinoma cell lines, NCI-H1563 and NCI-H2122, and for HeLa cervical carcinoma cells, but an EC50 greater than 1 µM for A549, MCF7, and PC3 cells.
Molecular Weight

304.34

Formula

C₁₅H₂₀N₄O₃

CAS No.

328104-79-6

SMILES

[O-][N+](C1=CC(C(C(C)C2)=NNC2=O)=CC=C1N(CC)CC)=O

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Keywords:

DNMDPPhosphodiesterase (PDE)cell-selectivecytotoxicitySchlafen 12PARPcleavageNCI-H1563NCI-H2122HeLacellsInhibitorinhibitorinhibit

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