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Cat. No.: HY-149348

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DiPT-4

DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance.

For research use only. We do not sell to patients.

CAS No.: 3052259-89-6
Formula: C₃₂H₂₂FN₅O₄S
Molecular Weight:591.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

DiPT-4 Chemical Structure

CAS No.: 3052259-89-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

All PARP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
MIA PaCa-2	IC₅₀	4.5 μM Compound: DiPT-4	Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MIA PaCa-2 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]
PANC-1	IC₅₀	4 μM Compound: DiPT-4	Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PANC-1 cells incubated for 72 hrs by MTT assay	[PMID: 37406384]

Chemical Information

CAS No. 3052259-89-6
Molecular Weight 591.61
Formula C₃₂H₂₂FN₅O₄S
SMILES

O=C1N(CC2=NN=C(SCCN3C(C4=CC=CC5=CC=CC(C3=O)=C45)=O)O2)N=C(CC6=CC=C(F)C=C6)C7=C1C=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guha Majumdar A, et al. Design, synthesis and development of a dual inhibitor of Topoisomerase 1 and poly (ADP-ribose) polymerase 1 for efficient killing of cancer cells. Eur J Med Chem. 2023 Oct 5;258:115598. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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DiPT-4

All Topoisomerase Isoforms

All PARP Isoforms