1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. CEP-9722

CEP-9722 

Cat. No.: HY-105303
Handling Instructions

CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects.

For research use only. We do not sell to patients.

CEP-9722 Chemical Structure

CEP-9722 Chemical Structure

CAS No. : 916574-83-9

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Description

CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].

IC50 & Target[2]

PARP-1

20 nM (IC50)

PARP-2

6 nM (IC50)

In Vivo

CEP-9722 (100-200 mg/kg/day; oral gavage; once daily; for 5 days a week for 4 weeks) shows dose-dependent antitumor activity in RT4 xenografts; 200 mg/kg daily is better than control and 100 mg/kg is not[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing subcutaneous RT4 human urothelial carcinoma (UC) tumors[1]
Dosage: 100 or 200 mg/kg/day
Administration: Oral gavage; once daily; for 5 days a week for 4 weeks
Result: Showed dose-dependent antitumor activity in RT4 xenografts.
Molecular Weight

418.49

Formula

C₂₄H₂₆N₄O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CEP-9722
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HY-105303
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