PARP1-IN-6
PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC50 values of 0.94 and 0.48 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1654735-36-0
- Formula: C16H11FN2O
- Molecular Weight:266.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Size
Price
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Quantity
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC50 values of 0.94 and 0.48 μM, respectively.
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CAL-27 | IC50 |
16 μM
Compound: DKD-NIPERA-3g
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Cytotoxicity against human CAL-27 cells assessed as reduction in cell viability incubated for 24 hrs by alamar blue assay
Cytotoxicity against human CAL-27 cells assessed as reduction in cell viability incubated for 24 hrs by alamar blue assay
|
[PMID: 36796126] |
| HeLa | IC50 |
1.5 μM
Compound: TP-3
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34670362] |
| HepG2 | IC50 |
0.9 μM
Compound: TP-3
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
|
[PMID: 34670362] |
| MCF-10A | IC50 |
>10 μM
Compound: TP-3
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34670362] |
| SK-OV-3 | IC50 |
1.7 μM
Compound: TP-3
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Cytotoxicity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human SK-OV-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
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[PMID: 34670362] |
Chemical Information
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CAS No. 1654735-36-0
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Molecular Weight 266.27
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Formula C16H11FN2O
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SMILES
O=C1C2=CC=CC=C2N=C(/C=C/C3=CC(F)=CC=C3)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
References
Calculators
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