1. Apoptosis
  2. Apoptosis
  3. Apoptosis inducer 9

Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents.

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Apoptosis inducer 9 Chemical Structure

Apoptosis inducer 9 Chemical Structure

CAS No. : 2551067-10-6

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Description

Apoptosis inducer 9 induces apoptosis with IC50 value of 4.21 μM. Apoptosis inducer 9 induces apoptosis through the mitochondrial pathway and enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Apoptosis inducer 9 can be used the potential to develop new anti-proliferative agents[1].

In Vitro

Apoptosis inducer 9 (Compound A1) (5-10 μM, 12 hours) induces apoptosis in HepG-2 cells in a concentration-dependent manner[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) triggers Cl-caspase-3, Cl-caspase-9 and Cl-PARP protein expression in HepG-2, thereby inducing apoptosis[1].
Apoptosis inducer 9 (Compound A1) (0-20 μM, 24 hours) induces apoptosis by triggering the mitochondrial apoptosis pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG-2 cells
Concentration: 5 and 10 μM
Incubation Time: 12 hours
Result: Apoptotic bodies appeared shrunken, nuclei shrunken and cells fragmented. The apoptosis rates at concentrations of 5 μM and 10 μM were 10.2% and 42.7%, respectively.

Western Blot Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Triggered the caspase cascade in HepG-2 and the corresponding protein expression gradually increased.

Western Blot Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0, 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Induced up-regulation of the expression of Bcl-2, Bax and p53 proteins, and increased the ratio of Bax/Bcl-2.
Molecular Weight

601.88

Formula

C34H55N3O4S

CAS No.
SMILES

C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@]3([H])[C@@]4(OC(C)(CCC4)C)C)C)O)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(CSC6=NN=CN6)=O)C)([H])CC1)C

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Apoptosis inducer 9
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HY-147897
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