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Referencia número: HY-157137

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PARP1-IN-17

PARP1-IN-17 is a PARP-1 inhibitor (IC₅₀ = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₄H₂₇FN₄O
Peso molecular:406.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PARP1-IN-17 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

PARP1-IN-17 is a PARP-1 inhibitor (IC₅₀ = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity^[1].

IC₅₀ & Target

PARP-1

Caspase 3

Ver todos los productos específicos de isoformas PARP :

Ver todos los productos específicos de isoformas Caspase :

In Vitro

PARP1-IN-17 (Compound 11b) (72 h) exhibits anti-proliferative effects in A549 cells, OVCAR-3 cells, HCT-116 cells and MCF-7 cells ^[1].
PARP1-IN-17 (1-4 μM, 48 h) can reduce the biosynthesis of PAR induce apoptosis in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A549 cells, OVCAR-3 cells, HCT-116 cells, MCF-7 cells
Concentration:
Incubation Time:

72 h
Result:

Had excellent anti-proliferative activity against A549 cell, OVCAR-3 cells, HCT-116 cells and MCF-7 cells (IC₅₀=1.95 ± 0.33 µM, 4.02 ± 0.24 µM, 7.45 ± 1.98 µM and 9.21 ± 2.54 µM).

Apoptosis Analysis^[1]

Cell Line:

A549 cells
Concentration:

1 μM, 2 μM, 4 μM
Incubation Time:

48 h
Result:

Induced apoptosis in cancer cells and increased the apoptosis rates of A549 cells in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

A549 cells, OVCAR-3 cells, HCT-116 cells, MCF-7 cells
Concentration:

1 μM, 2 μM, 4 μM
Incubation Time:
Result:

Reduced the biosynthesis of PAR, and had the best effect at 4.0 µM.
Decreased the expression of Caspase 3.

Related Protocols :

Chemical Information

Peso molecular 406.50
Fòrmula C₂₄H₂₇FN₄O
SMILES

OC1C2=CC=CC=C2C3(CCCCC3)N(CC4=CN(C5=CC=CC=C5F)N=N4)CC1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yu L, et al. Discovery of novel 2, 3, 4, 5-tetrahydrospiro [benzo [c] azepine-1, 1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors [J]. BMC chemistry, 2023, 17(1): 147. [Content Brief]

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Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PARP1-IN-17

Ver todos los productos específicos de isoformas PARP

Ver todos los productos específicos de isoformas Caspase

Actividad biológica

Descripciòn

IC50 & Target

In Vitro

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PARP1-IN-17 Related Classifications

HY-157137 Related Classifications

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